Journal: Scientific Reports

Article Title: Simulation of Subject-Specific Progression of Knee Osteoarthritis and Comparison to Experimental Follow-up Data: Data from the Osteoarthritis Initiative

doi: 10.1038/s41598-017-09013-7

Figure Lengend Snippet: Method for predicting the level of knee osteoarthritis using cartilage degeneration algorithm. ( A ) Knee joints ( N = 21) were manually segmented from MRI images taken from OAI database and 3D geometries were created. Gait obtained from literature , was implemented into the finite element models of the whole knee joint. ( B ) Medial compartment models were created to predict the level of medial knee OA (see justification behind that from Results section). Outcome force and rotations from the whole knee joint model were implemented into the compartment model to ensure similar knee joint motion in the compartment model as in the whole knee joint model. ( C ) Finally, cartilage degeneration algorithm was implemented into the medial compartment models to predict the level cartilage degeneration in three different KL groups (KL0, KL2 and KL3) after 100 iterations. In the algorithm, cartilage fibril degeneration occurs if tensile stress exceeds 7 MPa failure limit , decreasing collagen fibril network stiffness (See more details in Method section).

Article Snippet: The MR images were obtained with clinical 3 T MRI device (Siemens, Erlangen, Germany) using a dual-echo steady-state imaging sequence (SAG 3D DESS, TR = 16.32 ms, TE = 4.71 ms, flip angle = 25°, voxel size = 0.36 × 0.36 × 0.7 mm).

Techniques: